Extension of life-span with superoxide dismutase/catalase mimetics.
نویسندگان
چکیده
We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean life-span by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their life-span (a 67 percent increase). It appears that oxidative stress is a major determinant of life-span and that it can be counteracted by pharmacological intervention.
منابع مشابه
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ورودعنوان ژورنال:
- Science
دوره 289 5484 شماره
صفحات -
تاریخ انتشار 2000